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Adelmidrol, In Combination With Hyaluronic Acid, Displays Increased Anti-inflammatory And Analgesic Effects Against Monosodium Iodoacetate-induced Osteoarthritis In Rats
Aug 30, 2018

Di Paola et al. Arthritis  Research & Therapy (2016) 18:291

DOI 10.1186/s13075-016-118


Adelmidrol, In Combination With Hyaluronic Acid, Displays Increased Anti-inflammatory And Analgesic Effects


Scientifical research Conclusions on Adelmidrol, In Combination With Hyaluronic Acid :

The results  clearly  demonstrated that  a combination of HA and adelmidrol  dose dependently produced a significant reduction in: 

1)Adelmidrol, In Combination With Hyaluronic AcidReduction in pain severity; 

2)Adelmidrol, In Combination With Hyaluronic Acid Reduction in OA histopathology;

3)Adelmidrol, In Combination With Hyaluronic Acid Reduction in articular  cartilage degeneration;

4)Adelmidrol, In Combination With Hyaluronic AcidReduction in  mast cell infiltration;

5)Adelmidrol, In Combination With Hyaluronic AcidReduction in  pro-inflammatory cytokines, MMPs, and NGF produc- tion; 

6)Adelmidrol, In Combination With Hyaluronic AcidReduction in the degree of motor  function.


The   association   of Hyaluronic Acid (HA )  with  adelmidrol   is  accompanied  by  a  reduced   depolymerization  of  HA,  which would otherwise be promoted by intraarticular inflammation.

Moreover  application  of infiltrative adelmidrol  produces a  significant   increase   in  endogenous  PEA  levels, which are found to be significantly reduced in joint in- flammation. Several of our works demonstrated the beneficial effects of PEA alone and in combination in different  models  of inflammation and  pain, such as in a mouse model of collagen-induced arthritis  (CIA) . Thus,   local   analgesic    and    anti-inflammatory   effect sobserved with adelmidrol, treatment could be useful in the treatment of inflammatory  diseases associated with pain.


Keywords: Osteoarthritis, Adelmidrol, Sodium hyaluronate, Inflammation, Cartilage degeneration


BACKGROUND:

Osteoarthritis (OA) is a degenerative joint disease produced by a cascade of events that can ultimately lead to joint damage. The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis.

METHODS:

OA was induced by intra-articular injection of MIA in the knee joint. On day 21 post-MIA administration, the knee joint was analyzed. Rats subjected to OA were treated by intra-articular injection of adelmidrol in combination with sodium hyaluronate at different doses and time points after MIA induction. Limb nociception was assessed by the paw withdrawal latency and threshold measurement. Samples were examined macroscopically, histologically, and by immunohistochemistry.

RESULTS:

At day 21 post-MIA injection, the MIA + solvent and MIA + 1.0% sodium hyaluronate groups showed irregularities and fibrillation in the surface layer, a decrease in blood cells and multilayering in transition and radial zones, no pannus formation, and modified Mankin scores significantly higher than sham knees. The combination of hyaluronic acid and adelmidrol dose-dependently (adelmidrol 0.6% + 1.0% sodium hyaluronate and adelmidrol 2% + 1.0% sodium hyaluronate) reduced the histological alterations induced by MIA. Moreover, degeneration of articular cartilage, mast cell infiltration, and pro-inflammatory cytokine and chemokine plasma levels were significantly downregulated by treatment with a combination of hyaluronic acid and adelmidrol at the above doses.

CONCLUSIONS:

Our results clearly demonstrate that the combination of hyaluronic acid and adelmidrol improves the signs of OA induced by MIA


For more detailed scientific information,please see the original article at the following website:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153857/