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Palvanil,CAS No:69693-13-6

Palvanil,CAS No:69693-13-6

Palvanil
Product No GIHI-66
CAS NO 69693-13-6
Formula C24H41NO3
Molecular Weight 391.58724

  • Features & Specification


    Product NamePalvanil
    SynonymN-vanillyl-palmitamide; Hexadecanamide; N-[(4-hydroxy-3-methoxyphenyl)methyl]-N-[(4-Hydroxy-3-methoxyphenyl)methyl]hexadecanamide
    Product NoGIHI-66
    FormulaC24H41NO3
    CAS NO69693-13-6
    Molecular Weight391.58724
    PicturePalvanil,69693-13-6


    Product Quality

    NoItemSpecification
    1AppearanceWhite powder
    2Water0.5% max
    3StorageStore at room temperature
    4Instructionfood addiitive


    Specification and scientific background:

    1:Specification

    TargetTRPV1 channels

    SourceSynthetic

    Purity98%min

    FormulationWhite  powder.

    Chemical nameN-(4-hydroxy-3-methoxybenzyl)palmitamide.

    Molecular formulaC24H41NO3.

    CAS No.69693-13-6.

    ActivityPalvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin1.

    Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

    ReconstitutionDMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).

    Storage:Keep it under 25°C container


    2:Scientific background

    Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by capsaicin, protons, endogenous lipids, and hot temperature. Upon activation, TRPV1 initiates a signaling cascade that results in elevated levels of pain-inducing factors. It is located in sensory ganglia composed of neurons that send projection throughout the periphery1.


    N-palmitoyl-vanillamide (palvanil) is a TRPV1 agonist, a non-poignant analogue to capsaicin (capsaicinoid). It has a slower kinetic opening-onset than capsaicin, but it activates the channel more potently. It induces significantly milder side effects – e.g. imbalanced thermal homeostasis and bronchoconstriction - than capsaicin, and it seems to be suitable as a topical anti-analgesic. It is effective in reducing edema2, and can inhibit inflammatory and neuropathic pain3, and interestingly, in vitro data have shown that at low concentrations it encourages the proliferation of osteoclasts, and does the opposite at high concentrations4.



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